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PD-ECGF/Thymidine Phosphorylase Antibody (SPM322), DyLight 594, Novus Biologicals™
SDP

Catalog No. NB008170 Shop All R&D Systems Products
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NB008170 0.1 mL
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Catalog No. NB008170 Supplier Novus Biologicals Supplier No. NBP254403DL594
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Description

Mouse Monoclonal Antibody

PD-ECGF/Thymidine Phosphorylase Monoclonal specifically detects PD-ECGF/Thymidine Phosphorylase in Human, Mouse, Rat samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen PD-ECGF/Thymidine Phosphorylase
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM322
Conjugate DyLight 594
Dilution Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias EC 2.4.2, EC 2.4.2.4, ECGF, ECGF1TP, endothelial cell growth factor 1 (platelet-derived), Gliostatin, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, thymidine phosphorylase
Gene Symbols TYMP
Host Species Mouse
Immunogen Recombinant full-length human PD-ECGF/Thymidine Phosphorylase protein (Uniprot: P19971)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Angiogenesis
Primary or Secondary Primary
Test Specificity Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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