Invitrogen™ PD-L1 (CD274) Recombinant Rabbit Monoclonal Antibody (8E4V4)

Catalog No.	Quantity
PIMA537856	100 μL

Catalog No. PIMA537856

Supplier: Invitrogen™ MA537856

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: Raji.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

Specifications

• Antigen: PD-L1 (CD274)
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 8E4V4
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 1% BSA and <0.1% sodium azide; pH 7.3-7.7
• Gene: Cd274
• Gene Accession No.: Q9NZQ7
• Gene Alias: A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
• Gene Symbols: Cd274
• Host Species: Rabbit
• Immunogen: Recombinant protein of human PD-L1 extracellular domain.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 29126
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG