Invitrogen™ PD-L1 (CD274) Recombinant Rabbit Monoclonal Antibody (BLR020E)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544235

Catalog No. PIMA544235

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

Specifications

• Antigen: PD-L1 (CD274)
• Classification: Recombinant Monoclonal
• Concentration: 50 μg/mL
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q9NZQ7
• Gene Symbols: Cd274
• Immunogen: Synthetic peptide representing a region between residue 250 and the C-terminus (residue 290) of human programmed cell death 1 ligand 1 (PD-L1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Inhibition Assays, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: BLR020E
• Conjugate: Unconjugated
• Gene: Cd274
• Gene Alias: A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 29126
• Content And Storage: 4°C
• Form: Liquid