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Invitrogen™ PD-L1 Monoclonal Antibody (29E.2A3)
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Catalog No. PIMA544052
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100 μg
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PIMA544052 100 μg
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Catalog No. PIMA544052 Supplier Invitrogen™ Supplier No. MA544052
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas. Functional application: Blocking Immunohistochemistry (Frozen): Acetone fixation.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
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Specifications

Antigen PD-L1
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone 29E.2A3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene Cd274
Gene Accession No. Q9NZQ7
Gene Alias A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Symbols Cd274
Host Species Mouse
Immunogen Full length human CD274.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29126
Target Species Human, Monkey
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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