PD-L1 Monoclonal Antibody (OTI2B12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA507122

Catalog No. 50-167-6962

Description

PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.

Specifications

• Antigen: PD-L1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9NZQ7
• Gene Symbols: CD274
• Immunogen: Full length human recombit protein of human CD274 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2B12
• Conjugate: Unconjugated
• Gene: CD274
• Gene Alias: B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29126
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid