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PD-L1 Mouse anti-Human, Clone: OTI16H9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF810872

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.Specifications
PD-L1 | |
Monoclonal | |
Unconjugated | |
CD274 | |
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1 | |
Mouse | |
Affinity Chromatography | |
RUO | |
29126 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI16H9 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9NZQ7 | |
CD274 | |
Human recombit protein fragment corresponding to amino acids 19-290 of human CD274 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
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