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PD-L1 Mouse anti-Human, Clone: OTI16H9, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF810872

Encompass_Preferred

Catalog No. 50-167-0356


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.
Specifications

Specifications

PD-L1
Monoclonal
Unconjugated
CD274
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Mouse
Affinity Chromatography
RUO
29126
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI16H9
PBS with 8% trehalose and no preservative; pH 7.3
Q9NZQ7
CD274
Human recombit protein fragment corresponding to amino acids 19-290 of human CD274 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG2b
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