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PD-L1 Rabbit anti-Human, liquid, TrueRAB™

Rabbit Recombinant Monoclonal Antibody
Supplier: OriGene TA591003S

Description
PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.Specifications
PD-L1 | |
Recombinant Monoclonal | |
Unconjugated | |
CD274 | |
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
29126 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (Paraffin) | |
OR-5H8 | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q9NZQ7 | |
CD274 | |
Synthetic peptide within Human PD-L1 C-terminal. The exact sequence is proprietary. | |
30 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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