PD-L2/B7-DC/PDCD1LG2 Antibody (TY25) - BSA Free, Novus Biologicals™

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NB017709	Novus Biologicals NB100653320.025MG	0.025 mg
NB10065332	Novus Biologicals NB10065332	0.125 mg

Description

PD-L2/B7-DC/PDCD1LG2 Monoclonal specifically detects PD-L2/B7-DC/PDCD1LG2 in Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Immunohistochemistry-Frozen.

Specifications

• Antigen: PD-L2/B7-DC/PDCD1LG2
• Concentration: 1.0 mg/mL
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry, Immunoprecipitation, Flow Cytometry
• Conjugate: Unconjugated
• Host Species: Rat
• Target Species: Mouse
• Gene ID (Entrez): 80380
• Immunogen: B7-DC transfected RAW264.7 cells.
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

• Clone: TY25
• Dilution: Flow Cytometry 1:100-1:200, Immunohistochemistry 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Gene Alias: B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, CD273 antigen, CD273PD-1 ligand 2, MGC142240, PD-1-ligand 2, PDCD1L2MGC142238, PDL2B7DC, PD-L2PDCD1 ligand 2, programmed cell death 1 ligand 2, Programmed death ligand 2
• Gene Symbols: PDCD1LG2
• Isotype: IgG2a
• Purification Method: Protein G purified
• Test Specificity: NB100-65332 recognizes mouse CD273, a 42kD member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD274). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. Antibodies produced by clone TY25 are reported to block the binding of CD273 (B7-DC) to it's receptor.

For Research Use Only