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PDCD1 Monoclonal Antibody (OTI17B10), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA807851

Encompass_Preferred

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Catalog No. 50-168-1803


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Description

Description

PD-1 (Programmed Cell Death Protein 1, PCDP-1, CD279) is a cell surface receptor approximately 273-290 amino acids in length that inhibits cell-mediated immune responses initiated by T lymphocytes. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as lipopolysaccharide (LPS) associated with bacteria or pathogens. Evidence for this is seen in PD1-null mice who exhibit hyper-activated immune systems and autoimmune diseases. Further, expression of this gene in mice is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.
Specifications

Specifications

PDCD1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q02242, Q15116
Pdcd1
Full length human recombit protein of human PDCD1 produced in HEK293T cell.
100 μL
Primary
Human, Mouse
Antibody
IgG1
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI17B10
Unconjugated
PDCD1
CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Mouse
Affinity Chromatography
RUO
18566, 5133
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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