PDCD1 Mouse anti-Canine, Human, Mouse, Rat, Clone: UMAB197, liquid, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM870089

Catalog No. 50-168-5538

Description

PD-1 (Programmed Cell Death Protein 1, PCDP-1, CD279) is a cell surface receptor approximately 273-290 amino acids in length that inhibits cell-mediated immune responses initiated by T lymphocytes. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as lipopolysaccharide (LPS) associated with bacteria or pathogens. Evidence for this is seen in PD1-null mice who exhibit hyper-activated immune systems and autoimmune diseases. Further, expression of this gene in mice is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.

Specifications

• Antigen: PDCD1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PDCD1
• Gene Alias: CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18566, 301626, 486213, 5133
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: UMAB197
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q02242, Q15116
• Gene Symbols: Pdcd1
• Immunogen: Full length human recombit protein of human PDCD1 produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a