PDCD1 Mouse anti-Human, Clone: OTI22A9, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF808069
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOPD-1 (Programmed Cell Death Protein 1, PCDP-1, CD279) is a cell surface receptor approximately 273-290 amino acids in length that inhibits cell-mediated immune responses initiated by T lymphocytes. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as lipopolysaccharide (LPS) associated with bacteria or pathogens. Evidence for this is seen in PD1-null mice who exhibit hyper-activated immune systems and autoimmune diseases. Further, expression of this gene in mice is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.
|Full length human recombit protein of human PDCD1 produced in HEK293T cell.|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 8% trehalose and no preservative; pH 7.3|
|CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1|
|-20° C, Avoid Freeze/Thaw Cycles|
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