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PDCD1 Mouse anti-Human, Mouse, Clone: OTI7B4, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF807995

Catalog No. 50-166-8594


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

PD-1 (Programmed Cell Death Protein 1, PCDP-1, CD279) is a cell surface receptor approximately 273-290 amino acids in length that inhibits cell-mediated immune responses initiated by T lymphocytes. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as lipopolysaccharide (LPS) associated with bacteria or pathogens. Evidence for this is seen in PD1-null mice who exhibit hyper-activated immune systems and autoimmune diseases. Further, expression of this gene in mice is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.
Specifications

Specifications

PDCD1
Monoclonal
Unconjugated
PDCD1
Lyophilized
Pdcd1
Full length human recombit protein of human PDCD1 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry
OTI7B4
PBS with 8% trehalose and no preservative; pH 7.3
Q02242, Q15116
CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
18566, 5133
SDS
Documents
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