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Invitrogen™ PDCD2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA555388
Description
Immunogen sequence: PEQILRYGRG IAPIWISGEN IPQEKDIPDC PCGAKRILEF QVMPQLLNYL KADRLGKSID WGILAVFTCA ESCSLGTGYT EEFVWKQDVT DTP Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 91%.
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Specifications
PDCD2 | |
Polyclonal | |
Unconjugated | |
Pdcd2 | |
AI528543; hypothetical protein MGC63685; Pcd2; PDCD2; programmed cell death 2; programmed cell death protein 2; RP8; RP-8; zgc:63685; zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8; ZMYND7 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
18567, 5134, 58934 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P46718, P47816, Q16342 | |
Pdcd2 | |
Recombinant protein corresponding to Human PDCD2. Recombinant protein control fragment (Product #RP-92087). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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