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Invitrogen™ PDCD4 Polyclonal Antibody
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Catalog No. PIPA528150
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100 μL
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PIPA528150 100 μL
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Catalog No. PIPA528150 Supplier Invitrogen™ Supplier No. PA528150
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, HeLa, Mouse heart. Predicted reactivity: Mouse (97%), Rat (96%), Chicken (87%), Rhesus Monkey (98%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDCD4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene PDCD4
Gene Accession No. Q53EL6, Q61823
Gene Alias D19Ucla1; death up-regulated gene protein; death-upregulated; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; Pdcd4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; Protein 197/15a; protein MA-3; RP11-348N5.4; Tis; topoisomerase-inhibitor suppressed protein
Gene Symbols PDCD4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human PDCD4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18569, 27250
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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