Invitrogen™ PDCD4 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142913

Catalog No. PIPA5142913

Description

Additional Information: This antibody is expected to recognize all reported isoforms (NP_055271.2; NP_663314.1; NP_001186421.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.

Specifications

• Antigen: PDCD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDCD4
• Gene Alias: D19Ucla1; death up-regulated gene protein; death-upregulated; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; Pdcd4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; Protein 197/15a; protein MA-3; RP11-348N5.4; Tis; topoisomerase-inhibitor suppressed protein
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 18569, 27250
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q53EL6, Q61823
• Gene Symbols: PDCD4
• Immunogen: Peptide with sequence DSYKGTVDCVQAR.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov