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Invitrogen™ PDCD5 Polyclonal Antibody
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Catalog No. PIPA528998
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100 μL
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PIPA528998 100 μL
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Catalog No. PIPA528998 Supplier Invitrogen™ Supplier No. PA528998
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, HeLa, HCT116. Predicted reactivity: Mouse (95%), Rat (96%), Zebrafish (80%), Chicken (84%), Rhesus Monkey (100%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDCD5
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene PDCD5
Gene Accession No. O14737
Gene Alias 2200003D22Rik; AA408513; PDCD5; programmed cell death 5; programmed cell death protein 5; Protein TFAR19; TF1 cell apoptosis-related gene 19; TF-1 cell apoptosis-related protein 19; Tfar19; TFAR19 novel apoptosis-related
Gene Symbols PDCD5
Host Species Rabbit
Immunogen Full length human PDCD5 Recombinant protein.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9141
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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