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Tocris Bioscience™ PDD 00017273
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Catalog No. 59521
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.

Specifications

Chemical Name or Material 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS 1945950-21-9
Quantity 1 mg
Target PARG Inhibitors
Molecular Formula C23H26N6O4S2
Purity 98%
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