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Tocris Bioscience™ PDD 00017273
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Catalog No. 595210
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59-521-0 10 mg
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Description

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.

Specifications

Chemical Name or Material 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS 1945950-21-9
Quantity 10 mg
Solubility Soluble to 100mM in water and to 100mM in DMSO
Target PARG Inhibitors
Molecular Formula C23H26N6O4S2
Formula Weight 514.62
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%
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