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Tocris Bioscience™ PDD 00017273

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Quantity:
10 mg
Description
PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.
Specifications
Specifications
Chemical Name or Material | 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
CAS | 1945950-21-9 |
Quantity | 10 mg |
Solubility | Soluble to 100mM in water and to 100mM in DMSO |
Target | PARG Inhibitors |
Molecular Formula | C23H26N6O4S2 |
Formula Weight | 514.62 |
Physical Form | Solid |
Color | White |
Product Type | Bioactive Small Molecule |
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For Research Use Only.
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