Invitrogen™ PDE11A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532968

Catalog No. PIPA532968

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Hamster, Elephant, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Pufferfish, Zebrafish (100%); Platypus, Xenopus, Stickleback (94%); Dog (88%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PDE11A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE11A
• Gene Alias: 6330414F14Rik; A630086N24Rik; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; Gm350; MGC133355; MGC133356; Pde11a; PDE11A1; phosphodiesterase 11A; PPNAD2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100053692, 100341520, 100738835, 100756511, 140928, 241489, 424133, 50940, 524446, 561338
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.23 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P0C1Q2, Q8VID6, Q9HCR9
• Gene Symbols: PDE11A
• Immunogen: Synthetic 17 amino acid peptide from internal region of human PDE11A.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Chicken, Zebrafish, Bat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov