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Invitrogen™ PDE11A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532968

Catalog No. PIPA532968


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Description

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Hamster, Elephant, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Pufferfish, Zebrafish (100%); Platypus, Xenopus, Stickleback (94%); Dog (88%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PDE11A
Polyclonal
Unconjugated
PDE11A
6330414F14Rik; A630086N24Rik; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; Gm350; MGC133355; MGC133356; Pde11a; PDE11A1; phosphodiesterase 11A; PPNAD2
Rabbit
Antigen affinity chromatography
RUO
100053692, 100341520, 100738835, 100756511, 140928, 241489, 424133, 50940, 524446, 561338
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
0.23 mg/mL
PBS with 0.1% sodium azide
P0C1Q2, Q8VID6, Q9HCR9
PDE11A
Synthetic 17 amino acid peptide from internal region of human PDE11A.
50 μg
Primary
Human, Mouse, Rat, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Chicken, Zebrafish, Bat
Antibody
IgG
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