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Invitrogen™ PDE11A Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA532968
Description
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Hamster, Elephant, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Pufferfish, Zebrafish (100%); Platypus, Xenopus, Stickleback (94%); Dog (88%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications
PDE11A | |
Polyclonal | |
Unconjugated | |
PDE11A | |
6330414F14Rik; A630086N24Rik; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; Gm350; MGC133355; MGC133356; Pde11a; PDE11A1; phosphodiesterase 11A; PPNAD2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
100053692, 100341520, 100738835, 100756511, 140928, 241489, 424133, 50940, 524446, 561338 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.23 mg/mL | |
PBS with 0.1% sodium azide | |
P0C1Q2, Q8VID6, Q9HCR9 | |
PDE11A | |
Synthetic 17 amino acid peptide from internal region of human PDE11A. | |
50 μg | |
Primary | |
Human, Mouse, Rat, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Chicken, Zebrafish, Bat | |
Antibody | |
IgG |
Safety and Handling
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