Invitrogen™ PDE12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544028

Catalog No. PIPA544028

Description

Peptide sequence: FGLEGVFRIK QHEGLATFYR KSKFSLLSQH DISFYEALES DPLHKELLEK Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%.

PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Specifications

• Antigen: PDE12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE12
• Gene Alias: 2',5'-phosphodiesterase 12; 2',5'-phosphodiesterase 12-like protein; 2'-PDE; 2-PDE; 2'-phosphodiesterase; E430028B21Rik; fc58c05; fi42f03; LOC558284 protein; LOW QUALITY PROTEIN: 2',5'-phosphodiesterase 12; LRRGT00074; Mitochondrial deadenylase; PDE12; phosphodiesterase 12; RGD1310975; wu:fc58c05; wu:fi42f03; zgc:136374
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 201626
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q6L8Q7
• Gene Symbols: PDE12
• Immunogen: Synthetic peptide directed towards the C-terminal of human PDE12 (aa 368-417).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov