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Invitrogen™ PDE12 Polyclonal Antibody
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Catalog No. PIPA560267
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100 μL
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PIPA560267 100 μL
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Catalog No. PIPA560267 Supplier Invitrogen™ Supplier No. PA560267
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CGDFNSTPST GMYHFVINGS IPEDHEDWAS NGEEERCNMS LTHFFKLKSA CGEPAYTNYV GGFHGCLDYI FIDLNALEVE QVIPLPSHEE VTT Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 97%.

PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDE12
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PDE12
Gene Accession No. Q6L8Q7
Gene Alias 2',5'-phosphodiesterase 12; 2',5'-phosphodiesterase 12-like protein; 2'-PDE; 2-PDE; 2'-phosphodiesterase; E430028B21Rik; fc58c05; fi42f03; LOC558284 protein; LOW QUALITY PROTEIN: 2',5'-phosphodiesterase 12; LRRGT00074; Mitochondrial deadenylase; PDE12; phosphodiesterase 12; RGD1310975; wu:fc58c05; wu:fi42f03; zgc:136374
Gene Symbols PDE12
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PDE12. Recombinant protein control fragment (Product #RP-100240).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 201626
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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