Invitrogen™ PDE2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532970

Catalog No. PIPA532970

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Marmoset, Dog, Panda, Horse (100%); Gibbon, Monkey, Mouse, Rat, Bovine, Elephant, Rabbit (94%); Pig (88%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.

Specifications

• Antigen: PDE2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE2A
• Gene Alias: c-GMP stimulated phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated cyclic nucleotide phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; cGSPDE; CGS-PDE; cyclic GMP stimulated phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; cyclic nucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase 2a; Pde2; Pde2a; PDE2A1; Pde2a2; PED2A4; phosphodiesterase 2A; phosphodiesterase 2A, cGMP-stimulated
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100052619, 5138, 609574
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O00408
• Gene Symbols: PDE2A
• Immunogen: Synthetic 17 amino acid peptide from N-terminus of human PDE2A.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine, Horse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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