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PDE3B Rat anti-Mouse, Clone: SMCP3B, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$148.00 - $344.00

Specifications

Antigen PDE3B
Clone SMCP3B
Target Species Mouse
Conjugate Unconjugated
Isotype IgG2a, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-129-66 Non-distribution product as customer accommodation.
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Invitrogen
14197380
25 μg
Each for $148.00
Add to cart
 
50-129-67 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14197382
100 μg
Each for $344.00
Add to cart
 
Description

Description

Description: Cyclic nucleotide phosphodiesterases (PDE) catalyze the hydrolysis of cAMP and cGMP thereby regulating the effects of these second messengers. There are several families of PDE which share common structural organization. The PDE3 family has two members, 3A and 3B that are products of two separate genes. PDE3B (~130 kDa) is expressed predomitly in adipose tissue and lymphocytes, while PDE3A (~120 kDa) is expressed predomitly in platelets and heart tissue. The monoclonal antibody SMCP3B reacts with mouse PDE3B. The SMCP3B antibody was generated against amino acids 643-1100 in the C-terminus and does not cross-react with mouse PDE3A, as determined by western blot analysis of lysates of mouse heart tissue. The SMCP3B antibody does not cross-react with human PDE3B. Applications Reported: This SMCP3B antibody has been reported for use in immunoblotting (WB). Applications Tested: This SMCP3B antibody has been tested by immunoblotting of mouse lymph node cells and mouse heart under reducing conditions. It can be used at 1-5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Specifications

Specifications

PDE3B
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
SMCP3B
Unconjugated
Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.

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