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Invitrogen™ PDE6A Polyclonal Antibody
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Catalog No. PIPA5119904
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100 μL
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PIPA5119904 100 μL
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Catalog No. PIPA5119904 Supplier Invitrogen™ Supplier No. PA5119904
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Description

Rabbit Polyclonal Antibody

Positive Control: Rat eyeballs tissue lysate, K562 cell lysate, 293T cell lysate, rat kidney tissue lysate, Hela, rat eyeball tissue, mouse eyeball tissue. Subcellular Location: Cell membrane.

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDE6A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene PDE6A
Gene Accession No. P16499, P27664
Gene Alias cGMP phosphodiesterase alpha; cGMP phosphodiesterase alpha subunit; cGMP phosphodiesterase alpha subunit (EC 3.1.4.35); CGPR-A; cyclic GMP phosphodiesterase alpha subunit; GMP phosphodiesterase alpha subunit; GMP-PDE alpha; nmf282; PDE V-B1; PDE6A; PDEA; phosphodiesterase 6A; phosphodiesterase 6A, cGMP-specific, rod, alpha; phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; rod photoreceptor cGMP phosphodiesterase alpha subunit; RP43; unnamed protein product
Gene Symbols PDE6A
Host Species Rabbit
Immunogen Recombinant protein within human PDE6 alpha aa 201-400.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 225600, 307401, 5145
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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