PDE6A Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PA1721	100 μL

Catalog No. PA1721 Supplier Thermo Scientific Supplier No. PA1721

Description

Rabbit Polyclonal Antibody

PA1-721 detects phosphodiesterase 6 alpha’ (PDE6 alpha’) from sheep, human and bovine retinal extract. PA1-721 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ∽90 kDa protein representing PDE6 alpha’ from sheep and bovine retinal extract. The PA1-721 immunogen is a synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha’. This sequence is completely conserved between human, chicken and frog. PA1-721 immunizing peptide (Cat. No. PEP-149) is available for use in neutralization and control experiments.

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Specifications

• Antigen: PDE6A
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE6A
• Gene Accession No.: P11541, P16499
• Gene Alias: Phosphodiesterase 6 Alpha′
• Gene Symbols: PDE6A
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha’.
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 281973, 5145, 101122024
• Target Species: Bovine, Human, Ovine
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov