Invitrogen™ PDE6B Polyclonal Antibody

Catalog No.	Quantity
PIPA566293	100 μL

Catalog No. PIPA566293 Supplier Invitrogen™ Supplier No. PA566293

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSLSEEQARSF LDQNPDFARQ YFGKKLSPEN VAAACEDGCP PDCDSLRDLC QVEEST Highest antigen sequence identity to the following orthologs - mouse 81%, rat 79%.

The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

Specifications

• Antigen: PDE6B
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PDE6B
• Gene Accession No.: P35913
• Gene Alias: cGMP-phosphodiesterase beta-subunit; CSNB3; CSNBAD2; GMP-PDE beta; Mpb; PDE6B; PDEB; phosphodiesterase 6B; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; phosphodiesterase 6B, cGMP-specific, rod, beta; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd1; rd-1; rd10; retinal degeneration 1; rod cGMP-phosphodiesterase beta-subunit; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; RP40
• Gene Symbols: PDE6B
• Host Species: Rabbit
• Immunogen: Recombinant Human PDE6B. Recombinant protein control fragment (Product #RP-106974).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5158
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG