Invitrogen™ PDE6D Polyclonal Antibody

Catalog No.	Quantity
PA1726	100 μg

Catalog No. PA1726 Supplier Invitrogen™ Supplier No. PA1726

Description

Rabbit Polyclonal Antibody

PA1-726 detects PrBP/delta from bovine, human and sheep samples. PA1-726 has been successfully used in Western blot, ICC/IF and immunohistochemistry procedures. By Western blot, this antibody detects a 17 kDa protein representing PrBP/delta from bovine and sheep retinal/optic nerve extracts as well as HeLa cell lysate. Immunohistochemical staining of PrBP/delta in bovine retinal cross-sections using PA1-726 results in staining of retinal outer segments. PA1-726 immunizing peptides correspond to amino acid residues 1-16 from mouse and human PrBP/delta. This peptide (Cat. # PEP-203) is available for use in neutralization and control experiments.

PrBP/delta, previously known as PDE6/delta, is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). PRBP/delta has been implicated in the transport and membrane targeting of prenylated proteins (including PDE6) from their site of synthesis in the inner segment to their final destination in the outer segment of rods and cones (Norton et. al., 2005).

Specifications

• Antigen: PDE6D
• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene: PDE6D
• Gene Accession No.: O43924, Q95142
• Gene Alias: AI841218; GMP-PDE delta; JBTS22; PDE6D; PDED; phosphodiesterase 6D; phosphodiesterase 6D, cGMP-specific, rod, delta; PrBP/delta; Protein p17; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; rod phosphodiesterase delta subunit
• Gene Symbols: PDE6D
• Host Species: Rabbit
• Immunogen: Synthetic Peptides: M(1) S A K D E R A R (D/E) I L R G F K(16) C.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 101108369, 281976, 5147
• Target Species: Human, Bovine, Sheep
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG