Invitrogen™ PDE8A Polyclonal Antibody

Catalog No.	Quantity
PIPA532979	50 μg

Catalog No. PIPA532979

Supplier: Invitrogen™ PA532979

Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Panda, Horse, Rabbit, Pig (100%); Marmoset (94%); Mouse, Rat, Bovine, Elephant, Opossum (88%); Platypus, Zebrafish (81%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

Specifications

• Antigen: PDE8A
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% sodium azide
• Gene: Pde8a
• Gene Accession No.: O60658
• Gene Alias: AI551852; cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HsT19550; mmPDE8; Pde8; PDE8A; phosphodiesterase 8A; RNPDE8A
• Gene Symbols: Pde8a
• Host Species: Rabbit
• Immunogen: Synthetic 16 amino acid peptide from near N-terminus of human PDE8A.
• Purification Method: Antigen affinity chromatography
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100068475, 100343099, 100514527, 488752, 5151
• Target Species: Human, Canine, Rabbit, Pig, Horse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG