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Invitrogen™ PDE8A Polyclonal Antibody
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Catalog No. PIPA588405
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100 μL
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PIPA588405 100 μL
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Catalog No. PIPA588405 Supplier Invitrogen™ Supplier No. PA588405
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGCAPSIHIS ERLVAEDAPS PAAPPLSSGG PRLPQGQKTA ALPRTRGAGL LESELRDGSG KKVAVADVQF GPMRFHQDQL QVLLVFTKED NQCNGFCRAC EKAGFKCTVT KEAQAVLACF; Positive Samples: Mouse testis, Mouse eye, Mouse liver, Rat testis.

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDE8A
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Pde8a
Gene Accession No. O88502
Gene Alias AI551852; cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HsT19550; mmPDE8; Pde8; PDE8A; phosphodiesterase 8A; RNPDE8A
Gene Symbols Pde8a
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PDE8A (NP_0025961).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18584, 308776
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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