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Tocris Bioscience™ PDEdelta ATTEC 12C

Catalog No. 88245
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5 mg
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88-245 5 mg
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Catalog No. 88-245 Supplier Tocris Bioscience™ Supplier No. 8824/5
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Description

PDEδ autophagy-tethering compound (ATTEC) Degrader

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Specifications

Chemical Name or Material N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Quantity 5 mg
Target Active Degraders
Molecular Formula C41H42Br2IN7O5
Purity 98%
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