Invitrogen™ PDGF-C Polyclonal Antibody

Catalog No.	Quantity
PIPA582379	100 μL

Catalog No. PIPA582379 Supplier Invitrogen™ Supplier No. PA582379

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LDLLNNAITA FSTLEDLIRY LEPERWQLDL EDLYRPTWQL LGKAFVFGRK SRVVDLNLLT EEVLQLRPKT GVRGLHKSLT DVA Highest antigen sequence indentity to the following orthologs: Mouse - 60%, Rat - 55%.

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

Specifications

• Antigen: PDGF-C
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PDGFC
• Gene Accession No.: Q9NRA1
• Gene Alias: 1110064L01Rik; AI647969; C76851; fallotein; MGC102297; Pdgfc; PDGF-C; PDGFC latent form; PDGFC receptor-binding form; platelet derived growth factor C; platelet-derived growth factor C; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form; platelet-derived growth factor, C polypeptide; rScdfg; Scdgf; secretory growth factor-like protein; spinal cord-derived growth factor; UNQ174/PRO200; VEGF-E
• Gene Symbols: PDGFC
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PDGFC. Recombinant protein control fragment (Product #RP-89554).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56034
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG