PDGF-C Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA112720

Catalog No. 01-674-850

Description

A suggested positive control for this product is active recombinant sphingosine kinase enzyme.

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

Specifications

• Antigen: PDGF-C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDGFC
• Gene Alias: 1110064L01Rik; AI647969; C76851; fallotein; MGC102297; Pdgfc; PDGF-C; PDGFC latent form; PDGFC receptor-binding form; platelet derived growth factor C; platelet-derived growth factor C; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form; platelet-derived growth factor, C polypeptide; rScdfg; Scdgf; secretory growth factor-like protein; spinal cord-derived growth factor; UNQ174/PRO200; VEGF-E
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54635, 56034, 79429
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: Q8CI19, Q9EQX6, Q9NRA1
• Gene Symbols: PDGFC
• Immunogen: Synthetic peptide derived from the N-terminal region of Sphingosine Kinase 2
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov