Invitrogen™ PDGF-D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114143

Catalog No. PIPA5114143

Description

Immunogen sequence: NANLRRDESN HLTDLYRRDE TIQVKGNGYV QSPRFPNSYP RNLLLTWRLH For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%.

The platelet-derived growth factor (PDGF) family consists of four members; PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-a and PDGFR-b, and PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and by stimulation of tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines including those derived from ovarian, renal and lung cancers, as well as from astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.

Specifications

• Antigen: PDGF-D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pdgfd
• Gene Alias: 1110003I09Rik; Iegf; Iris-expressed growth factor; MSTP036; Pdgfd; PDGF-D; PDGFD latent form; PDGFD receptor-binding form; platelet derived growth factor D; platelet-derived growth factor D; Platelet-derived growth factor D, latent form; Platelet-derived growth factor D, receptor-binding form; platelet-derived growth factor, D polypeptide; rSCDGF-B; SCDGFB; SCDGF-B; spinal cord derived growth factor B; spinal cord-derived growth factor B; spinal cord-derived growth factor-B; spinal-cord derived growth factor-B protein; UNQ1899/PRO4345
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80310
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9GZP0
• Gene Symbols: Pdgfd
• Immunogen: Synthetic peptide directed towards the N terminal region of human PDGFD (aa 35-84).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov