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PDGFD Monoclonal Antibody (OTI1C1), TrueMAB™, OriGene
SDP

Catalog No. 501674533
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30 μL
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50-167-4533 100 μL
50-254-0753 30 μL
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Catalog No. 50-167-4533 Supplier OriGene Supplier No. TA503700
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Description

Mouse Monoclonal Antibody

The platelet-derived growth factor (PDGF) family consists of four members; PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-a and PDGFR-b, and PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and by stimulation of tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines including those derived from ovarian, renal and lung cancers, as well as from astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.

Specifications

Antigen PDGFD
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI1C1
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene PDGFD
Gene Accession No. Q9GZP0
Gene Alias IEGF, MSTP036, SCDGF-B, SCDGFB
Gene Symbols PDGFD
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 19-247 of human PDGFD produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80310
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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