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Invitrogen™ PDGFRB Recombinant Rabbit Monoclonal Antibody (RM303)
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Catalog No. PIMA533050
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100 μL
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PIMA533050 100 μL
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Catalog No. PIMA533050 Supplier Invitrogen™ Supplier No. MA533050
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: reacts to human CD140b (PDGFR-beta) (Platelet-derived growth factor receptor beta). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDGFRB
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone RM303
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Pdgfrb
Gene Accession No. P09619
Gene Alias AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
Gene Symbols Pdgfrb
Host Species Rabbit
Immunogen A peptide corresponding to the C-terminus of human CD140b.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5159
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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