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Invitrogen™ PDIR Polyclonal Antibody
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Catalog No. PIPA589796
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100 μL
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PIPA589796 100 μL
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Catalog No. PIPA589796 Supplier Invitrogen™ Supplier No. PA589796
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSAKVSSLIE RISDPKDLKK LLRTRNNVLV LYSKSEVAAE NHLRLLSTVA QAVKGQGTIC WVDCGDAESR KLCKKMKVDL SPKDKKVELF HYQDGAFHTE YNRAVTFKSI VAFLKDPKG; Positive Samples: Mouse kidney, Mouse liver, Mouse pancreas, Rat liver; Cellular Location: Endoplasmic reticulum lumen.

PDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal 'Lys-Glu-Glu-Leu' at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDIR
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.78 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PDIA5
Gene Accession No. Q5I0H9, Q921X9
Gene Alias 2700053F16Rik; AU015525; Pdia5; PDIR; protein disulfide isomerase A5; protein disulfide isomerase associated 5; protein disulfide isomerase family A member 5; protein disulfide isomerase family A, member 5; protein disulfide isomerase-associated 5; protein disulfide isomerase-related protein; Protein disulfide-isomerase A5
Gene Symbols PDIA5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-140 of human PDIA5 (NP_0068011).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 360722, 72599
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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