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Invitrogen™ PDK4 Polyclonal Antibody
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Catalog No. PIPA522984
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100 μL
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Catalog No. Quantity
PIPA522984 100 μL
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Catalog No. PIPA522984 Supplier Invitrogen™ Supplier No. PA522984
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Description

Rabbit Polyclonal Antibody

The target sequence has 94% sequence homology with rat and 88% sequence homology with mouse. Suggested positive control: antigen standard for PDK4 (transient overexpression lysate), human heart protein lysate.

PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhibition of PDHKs is viewed as a potential therapeutic treatment for type II diabetes. This protein is located in the matrix of the mitrochondria and it's expression is regulated by glucocorticoids, retinoic acid and insulin. PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDK4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.24 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.1% sodium azide
Gene Pdk4
Gene Accession No. Q16654
Gene Alias [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; AV005916; kinase isozyme 4; lipoamide; PDHK4; Pdk4; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 4; Pyruvate dehydrogenase kinase isoform 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; pyruvate dehydrogenate kinase 4
Gene Symbols Pdk4
Host Species Rabbit
Immunogen Synthetic peptide made to an internal portion of the human PDK4 protein (within residues 200-250).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5166
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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