Invitrogen™ PDK4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110092

Catalog No. PIPA5110092

Description

Immunogen sequence: FHEKSPDDQK ALSDFVDTLI KVRNRHHNVV PTMAQGIIEY KDACTVDPVT NQNLQYFLDR FYMNRISTRM LMNQHILIFS DSQTGNPSHI GSIDPNCDVV AVVQDAFECS RMLCDQYYLS SPELKLTQVN GKFPDQPIHI VYVPSHLHHM LFELFKNAMR ATVEHQENQP SLTPIEVIVV LGKEDLTIKI SDRGGGVPLR IIDRLFSYTY STAPTPVMDN SRNAPLAGFG YGLPISRLYA KYFQGDLNLY SLSGYGTDAI IYLKALSSES IEKLPVFNKS AFKHYQMSSE ADDWCIPSRE PKNLAKEVAM.

PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhibition of PDHKs is viewed as a potential therapeutic treatment for type II diabetes. This protein is located in the matrix of the mitrochondria and it's expression is regulated by glucocorticoids, retinoic acid and insulin. PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Specifications

• Antigen: PDK4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pdk4
• Gene Alias: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; AV005916; kinase isozyme 4; lipoamide; PDHK4; Pdk4; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 4; Pyruvate dehydrogenase kinase isoform 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; pyruvate dehydrogenate kinase 4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27273, 5166, 89813
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O54937, O70571, Q16654
• Gene Symbols: Pdk4
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 102-411 of human PDK4 (NP_0026031).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG