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Invitrogen™ PDK4 Polyclonal Antibody
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Catalog No. PIPA5110092
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100 μL
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PIPA5110092 100 μL
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Catalog No. PIPA5110092 Supplier Invitrogen™ Supplier No. PA5110092
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FHEKSPDDQK ALSDFVDTLI KVRNRHHNVV PTMAQGIIEY KDACTVDPVT NQNLQYFLDR FYMNRISTRM LMNQHILIFS DSQTGNPSHI GSIDPNCDVV AVVQDAFECS RMLCDQYYLS SPELKLTQVN GKFPDQPIHI VYVPSHLHHM LFELFKNAMR ATVEHQENQP SLTPIEVIVV LGKEDLTIKI SDRGGGVPLR IIDRLFSYTY STAPTPVMDN SRNAPLAGFG YGLPISRLYA KYFQGDLNLY SLSGYGTDAI IYLKALSSES IEKLPVFNKS AFKHYQMSSE ADDWCIPSRE PKNLAKEVAM.

PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhibition of PDHKs is viewed as a potential therapeutic treatment for type II diabetes. This protein is located in the matrix of the mitrochondria and it's expression is regulated by glucocorticoids, retinoic acid and insulin. PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDK4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.72 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Pdk4
Gene Accession No. O54937, O70571, Q16654
Gene Alias [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; AV005916; kinase isozyme 4; lipoamide; PDHK4; Pdk4; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 4; Pyruvate dehydrogenase kinase isoform 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; pyruvate dehydrogenate kinase 4
Gene Symbols Pdk4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 102-411 of human PDK4 (NP_0026031).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27273, 5166, 89813
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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