Invitrogen™ PDLIM1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518234

Catalog No. PIPA518234

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.

Specifications

• Antigen: PDLIM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pdlim1
• Gene Alias: carboxyl terminal LIM domain protein 1; Clim1; Clp36; CLP-36; C-terminal LIM domain protein 1; elfin; enigma; epididymis secretory protein Li 112; hCLIM1; HEL-S-112; LIM domain protein CLP-36; LIM protein; mClim1; Pdlim1; PDZ and LIM domain 1; PDZ and LIM domain 1 (elfin); PDZ and LIM domain protein 1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 9124
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00151
• Gene Symbols: Pdlim1
• Immunogen: Synthetic peptide sequence (TPPEGYEVVTVFPK) corresponding to the C-terminus amino acids of PDLIM1 (aa 316-329).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG