Invitrogen™ PDLIM1 Polyclonal Antibody

Catalog No.	Quantity
PIPA528701	100 μL

Catalog No. PIPA528701 Supplier Invitrogen™ Supplier No. PA528701

Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.

Specifications

• Antigen: PDLIM1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene: Pdlim1
• Gene Accession No.: O00151
• Gene Alias: carboxyl terminal LIM domain protein 1; Clim1; Clp36; CLP-36; C-terminal LIM domain protein 1; elfin; enigma; epididymis secretory protein Li 112; hCLIM1; HEL-S-112; LIM domain protein CLP-36; LIM protein; mClim1; Pdlim1; PDZ and LIM domain 1; PDZ and LIM domain 1 (elfin); PDZ and LIM domain protein 1
• Gene Symbols: Pdlim1
• Host Species: Rabbit
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PDLIM1. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9124
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov