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Invitrogen™ PDPK1/PDPK2/PDPK3 Polyclonal Antibody
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Catalog No. PIPA536113
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100 μL
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PIPA536113 100 μL
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Catalog No. PIPA536113 Supplier Invitrogen™ Supplier No. PA536113
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 90-140 kDa. Purity is >95% by SDS-PAGE.

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDPK1/PDPK2/PDPK3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PRKD3
Gene Accession No. O94806, Q15139, Q5XIS9, Q62101, Q8BZ03, Q8K1Y2, Q9BZL6, Q9WTQ1
Gene Alias 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; Pkcm; PKC-MU; Pkcnu; PKC-NU; PKD; PKD1; PKD2; PKD3; Prkcm; Prkcn; Prkd1; PRKD2; Prkd3; Protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase D1; protein kinase D2; protein kinase D3; protein kinase EPK2; RGD1308054; Serine/threonine-protein kinase D1; serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
Gene Symbols PRKD1, PRKD2, PRKD3
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 708-763 of human PKD1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101540, 18760, 23683, 25865, 292658, 313834, 5587, 75292, 85421
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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