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Pds1 Monoclonal Antibody (DCS-280), Invitrogen™

Catalog No. PIMA512252
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500 μL
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PIMA512252 500 μL
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Catalog No. PIMA512252 Supplier Thermo Scientific Supplier No. MA512252
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Description

Mouse Monoclonal Antibody

IHC staining of formalin-fixed tissues requires boiling in 10mM citrate buffer, pH 6.0, for 10-20 minutes, followed by cooling at room temperature for 20 minutes. HeLa or tonsil tissues can be used as positive controls.

Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pds1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone DCS-280
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene IGF2
Gene Accession No. P01344, P09535
Gene Alias AL033362; C11orf43; GRDF; Igf2; Igf-2; IGF-II; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; M6pr; Mpr; multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor
Gene Symbols IGF2
Host Species Mouse
Immunogen Human recombinant full length Pds1 protein
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16002, 3481
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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