PDX1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA587695
Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF; Positive Samples: DU145, HepG2, Mouse pancreas, Mouse liver; Cellular Location: Cytoplasm, Nucleus, cytosolPDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in its gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
|A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1|
|Human, Mouse, Rat|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P52945, P52946, P52947|
|Antigen Affinity Chromatography|
|18609, 29535, 3651|
|-20° C, Avoid Freeze/Thaw Cycles|
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