PDX1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587695

Catalog No. PIPA587695

Description

Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF; Positive Samples: DU145, HepG2, Mouse pancreas, Mouse liver; Cellular Location: Cytoplasm, Nucleus, cytosol

PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in its gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Specifications

• Antigen: PDX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDX1
• Gene Symbols: PDX1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 2.27 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P52945, P52946, P52947
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18609, 29535, 3651
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid