PDX1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587695

Catalog No. PIPA587695

Description

Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF; Positive Samples: DU145, HepG2, Mouse pancreas, Mouse liver; Cellular Location: Cytoplasm, Nucleus, cytosol

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Specifications

• Antigen: PDX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDX1
• Gene Alias: DLDBP, E3BP, Glucose-sensitive factor, GSF, Idx1, IDX-1, Insulin promoter factor 1, insulin promoter factor 1, homeodomain transcription factor, insulin promotor factor 1, insulin upstream factor 1, Ipf1, IPF-1, Islet/duodenum homeobox 1, islet/duodenum homeobox-1, IUF1, IUF-1, MODY4, PAGEN1, Pancreas/duodenum homeobox protein 1, pancreatic and duodenal homeobox 1, pancreatic and duodenal homeobox gene 1, pancreatic-duodenal homeobox factor 1, PDHX, PDX1, pdx-1, somatostatin transactivating factor 1, somatostatin transcription factor 1, somatostatin-transactivating factor 1, Stf1, STF-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18609, 3651
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: P52945, P52946
• Gene Symbols: PDX1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1 (NP_0002001)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov