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Invitrogen™ PDXK Monoclonal Antibody (1007CT2.1.1)
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Catalog No. PIMA537743
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200 μL
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PIMA537743 200 μL
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Catalog No. PIMA537743 Supplier Invitrogen™ Supplier No. MA537743
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Description

Mouse Monoclonal Antibody

PDXK Monoclonal Antibody for Western Blot, IHC (P)

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDXK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1007CT2.1.1
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene PDXK
Gene Accession No. O00764
Gene Alias 2310036D04Rik; AA119688; C21orf124; C21orf97; C77999; epididymis secretory sperm binding protein Li 1a; HEL-S-1a; Pdxk; Pkh; PNK; PRED79; pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase
Gene Symbols PDXK
Host Species Mouse
Immunogen recombinant protein between 1-312 amino acids from human PDXK.
Purification Method Protein G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8566
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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