PDXK Mouse anti-Human, Clone: OTI5H5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF502998

Catalog No. 50-166-1800

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

Specifications

• Antigen: PDXK
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PDXK
• Gene Alias: C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8566
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5H5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O00764
• Gene Symbols: PDXK
• Immunogen: Full length human recombit protein of human PDXK produced in HEK293 cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a