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Invitrogen™ PDXK Polyclonal Antibody
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Catalog No. PIPA556393
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100 μL
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PIPA556393 100 μL
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Catalog No. PIPA556393 Supplier Invitrogen™ Supplier No. PA556393
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LLPVYKEKVV PLADIITPNQ FEAELLSGRK IHSQEEALRV MDMLHSMGPD TVVITSSDLP SPQGSNYLIV LGSQ Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDXK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PDXK
Gene Accession No. O00764
Gene Alias 2310036D04Rik; AA119688; C21orf124; C21orf97; C77999; epididymis secretory sperm binding protein Li 1a; HEL-S-1a; Pdxk; Pkh; PNK; PRED79; pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase
Gene Symbols PDXK
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PDXK. Recombinant protein control fragment (Product #RP-95173).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8566
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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