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PDZ-RhoGEF Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31 - $568.26

Specifications

Antigen PDZ-RhoGEF
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-157-2344
Encompass_Preferred
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Bethyl Laboratories, Inc
IHC00581T
10 μL
Each for $151.31
Only null left
Add to Cart
 
50-157-2343
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
IHC00581
100 μL
Each for $568.26
Only null left
Add to Cart
 
Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Gorilla and Chimpanzee

ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
Specifications

Specifications

PDZ-RhoGEF
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
RP11-356J7.2, GTRAP48, PDZ-RHOGEF, Rho guanine exchange factor (GEF) 11, RhoA-specific guanine nucleotide exchange factor, RhoGEF glutamate transport modulator, glutamate transporter EAAT4-associated protein 48, rho guanine nucleotide exchange factor 11
ARHGEF11
IgG
Antigen affinity chromatography
Antibody
Immunohistochemistry
Unconjugated
Rabbit
Human
O15085
9826
Between 1472 and 1522
Primary
4° C
ARHGEF11
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