Invitrogen™ PDZK1 Polyclonal Antibody

Catalog No.	Quantity
PIPA552261	100 μL

Catalog No. PIPA552261 Supplier Invitrogen™ Supplier No. PA552261

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ DGDRVLRING VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAV Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

Specifications

• Antigen: PDZK1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PDZK1
• Gene Accession No.: Q5T2W1, Q9JIL4, Q9JJ40
• Gene Alias: 1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; CAP70; CFTR-associated protein of 70 kDa; Clamp; C-terminal linking and modulating protein; C-terminal-linking and modulating protein; D3Ertd537e; Dietary Pi-regulated RNA-1; Diphor1; diphor-1; mPDZK1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-C; naPi-Cap1; NHERF3; NHERF-3; PDZ domain containing 1; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; Pdzd1; PDZK 1; Pdzk1; PDZK-1; Sodium-hydrogen exchanger regulatory factor 3
• Gene Symbols: PDZK1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PDZK1. Recombinant protein control fragment (Product #RP-88792).
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5174, 59020, 65144
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG