Invitrogen™ PDZK1 Recombinant Rabbit Monoclonal Antibody (5C1D3)

Catalog No.	Quantity
PIMA542898	100 μL

Catalog No. PIMA542898 Supplier Invitrogen™ Supplier No. MA542898

Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HepG2. Immunogen sequence: EDVIIEVNGV NVLDEPYEKV VDRIQSSGKN VTLLVCGKKA YDYFQAKKIP IVSSLADPLD TPPDSKEGIV VESNHDSHMA KERAHSTASH SSSNSEDTEM.

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

Specifications

• Antigen: PDZK1
• Applications: ELISA, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 5C1D3
• Concentration: 0.49 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PDZK1
• Gene Accession No.: Q5T2W1, Q9JIL4, Q9JJ40
• Gene Alias: 1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; CAP70; CFTR-associated protein of 70 kDa; Clamp; C-terminal linking and modulating protein; C-terminal-linking and modulating protein; D3Ertd537e; Dietary Pi-regulated RNA-1; Diphor1; diphor-1; mPDZK1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-C; naPi-Cap1; NHERF3; NHERF-3; PDZ domain containing 1; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; Pdzd1; PDZK 1; Pdzk1; PDZK-1; Sodium-hydrogen exchanger regulatory factor 3
• Gene Symbols: PDZK1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 420-519 of human PDZK1 (Q5T2W1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5174, 59020, 65144
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov