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PECAM1 Mouse anti-Human, Biotin, Clone: OTI2E4, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA700245

Encompass_Preferred

Catalog No. 50-167-7760


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Description

Description

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. The N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. Further, CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. CD31 is one of key regulatory molecules in the vascular system. CD31 induces susceptibility to atherosclerosis and this cell adhesion molecule is required for leukocyte migration under most inflammatory conditions. Antibodies to CD31 is of value in the study of benign and maligt vascular tumors.
Specifications

Specifications

PECAM1
OTI2E4
Biotin
PECAM1
CD31, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, endoCAM
Mouse
Affinity Chromatography
RUO
5175
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Monoclonal
0.5 mg/mL
PBS with 10mg/ml BSA, 50% glycerol and 0.05% sodium azide
P16284
PECAM1
Full length human recombit protein of human PECAM1 produced in HEK293T cell.
50 μg
Primary
Human
Antibody
IgG1
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